PAI-1 4G/5G polymorphism
- Useful for:
The PAI-1 4G/5G polymorphism is a common genetic variation in the promoter region of the SERPINE1 gene, which controls the production of Plasminogen Activator Inhibitor-1 (PAI-1). PAI-1 is the primary inhibitor of tissue plasminogen activator (tPA), meaning it blocks the body's ability to dissolve blood clots (fibrinolysis). The single nucleotide deletion/insertion variant creates either a sequence of four guanine bases (4G) or five guanine bases (5G), directly dictating baseline blood clotting tendencies.
- Method Name: Polymerase Chain Reaction (PCR)
- Other Common Names: N/A
- Medicover Laboratories Code Name: 8363
- Fasting or other requirements: N/A
- Specimen Type: EDTA WHOLE BLOOD
- Specimen Required Supplies: EDTA whole blood tube, purple top
- Specimen Volume: 2 ml
- Specimen retention time: 7 days
- Report Available: 2-3 working days
